Tumors composed of malignant epithelial and melanocytic populations: a case series and review of the literature


  • The authors report no conflict of interest.

    The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense or the United States Government.

Dr Elizabeth K. Satter, MD, MPH, Departments of Dermatology and Pathology, Naval Medical Center, 34520 Bob Wilson Drive, Suite 300, San Diego, CA 92134-2300, USA
Tel: 619 532 9702
Fax: 619 532 9458
e-mail: elizabeth.satter@med.navy.mil


Over the last 30 years, there have been approximately 49 case reports of tumors composed of both malignant epithelial and malignant melanocytic populations. Herein, we present four additional cases of combined tumors that consist of two phenotypically distinct but intermingled populations of malignant cells. Each tumor was composed of an invasive melanoma closely associated with either a basal cell carcinoma or a squamous cell carcinoma. We review all previous case reports in the English literature and attempt to clarify the terminology and summarize what is currently known about these unique tumors.