Conflicts of interest: none declared.
The limited specificity of histological examination in the diagnosis of dysplastic nevi
Article first published online: 16 OCT 2008
© Blackwell Munksgaard 2008
Journal of Cutaneous Pathology
Special Issue: Festschrift in Honor of N. Scott McNutt, MD
Volume 35, Issue Supplement s2, pages 20–23, November 2008
How to Cite
Rabkin, M. S. (2008), The limited specificity of histological examination in the diagnosis of dysplastic nevi. Journal of Cutaneous Pathology, 35: 20–23. doi: 10.1111/j.1600-0560.2008.01131.x
- Issue published online: 16 OCT 2008
- Article first published online: 16 OCT 2008
- Accepted for publication July 2, 2008
Dysplastic nevi were originally described as a distinct entity with specific clinical and histological features of importance as direct precursors of malignant melanoma and as markers of patients at increased risk of developing melanoma in the setting of familial melanoma. Nevi with the clinical and histological features described first as ‘B-K moles’ and later as ‘dysplastic nevi’ clearly do exist and do sometimes represent melanoma precursors or melanoma risk markers, but it is now recognized that most dysplastic nevi never progress to melanoma, that the histological features originally described in nevi in familial melanoma patients are poorly correlated with dysplastic nevi as they are defined clinically, and that overlapping or identical histological features are found in a variety of other melanocytic lesions including small (< 5 mm) melanocytic nevi, lentiginous nevi, atypical (dysplastic) lentiginous nevi, lentiginous melanoma, lentigo maligna and nevi in an ever-growing number of ‘special sites’. This article will briefly review the evolution of our understanding of the histological range of nevi and the histological differential diagnosis of dysplastic nevi.