Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides

  1. Maria Ioannou1,
  2. Fani Sourli2,
  3. Ilias Mylonis3,
  4. Sotirios Barbanis1,
  5. Rodula Papamichali1,
  6. Evangelos Kouvaras1,
  7. Efterpi Zafiriou2,
  8. Paraskevi Siomou2,
  9. Eleni Klimi2,
  10. George Simos3,
  11. Aggeliki-Victoria Roussaki-Schulze2,
  12. George Koukoulis1,*

Article first published online: 26 JUN 2009

DOI: 10.1111/j.1600-0560.2009.01264.x

Issue

Journal of Cutaneous Pathology

Journal of Cutaneous Pathology

Volume 36, Issue 12, pages 1255–1261, December 2009

Additional Information

How to Cite

Ioannou, M., Sourli, F., Mylonis, I., Barbanis, S., Papamichali, R., Kouvaras, E., Zafiriou, E., Siomou, P., Klimi, E., Simos, G., Roussaki-Schulze, A.-V. and Koukoulis, G. (2009), Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides. Journal of Cutaneous Pathology, 36: 1255–1261. doi: 10.1111/j.1600-0560.2009.01264.x

Author Information

  1. 1

    Department of Pathology, Medical School, University of Thessaly

  2. 2

    Department of Dermatology, Medical School, University of Thessaly

  3. 3

    Department of Biochemistry, Medical School, University of Thessaly

*George K. Koukoulis, MD, PhD, Professor of Pathology, Department of Pathology, Medical School, University of Thessaly, Kanavatzoglou 17 Larissa 41334, Greece Tel: (0030) 2410 685548 Fax: (0030) 2410 670113 e-mail: poroi@otenet.gr

Publication History

  1. Issue published online: 26 OCT 2009
  2. Article first published online: 26 JUN 2009
  3. Accepted for publication January 16, 2009

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Background: Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha overexpression in psoriatic lesional keratinocytes.

Methods: In this study we have employed a carefully selected panel of antibodies and quantitative morphometric analysis to compare HIF-1 alpha immunoreactivity in psoriatic biopsy samples vs. that in samples obtained from psoriasiform dermatitides.

Results: We found statistically significant HIF-1 alpha overexpression in psoriasis. Furthermore, we observed a previously unreported preferential localization of immunoreactive keratinocytes in the immediate vicinity of inflamed and elongated papillae. This pattern of immunoreactivity may partially account for the observed increase of HIF-1 alpha immunostaining in psoriasis.

Conclusions: Overall, our findings imply that possible novel therapeutic intervention(s) on the HIF-1 alpha pathway may offer another approach in controlling the inflammatory activity of psoriatic lesions.

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