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The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions

Authors

  • Alistair J. Cochran,

    Corresponding author
    1. Department of Pathology and Laboratory Medicine
    2. Department of Surgery
    3. The Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA
    4. The John Wayne Cancer Institute at Saint John's Hospital and Health Center, Santa Monica, CA, USA
      Alistair J. Cochran, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue 13-145CCMS, 173216 Los Angeles, CA 90095–1732, USA
      Tel: +1 310 825 2743
      Fax: +1 310 267 2058
      e-mail: ACochran@mednet.ucla.edu
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  • Scott Binder,

    1. Department of Pathology and Laboratory Medicine
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  • Donald L. Morton

    1. The John Wayne Cancer Institute at Saint John's Hospital and Health Center, Santa Monica, CA, USA
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Alistair J. Cochran, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue 13-145CCMS, 173216 Los Angeles, CA 90095–1732, USA
Tel: +1 310 825 2743
Fax: +1 310 267 2058
e-mail: ACochran@mednet.ucla.edu

Abstract

Atypical and anomalous melanocytic lesions are tumors that cannot be determined by microscopy to be certainly benign or fully malignant. The malignant potential of these borderline lesions is unknown and logical determination of best therapy is challenging, in particular whether lymphatic mapping and sentinel node biopsy have a place in their management. Lesions that fall into this category include atypical Spitzoid lesions, atypical cellular blue nevi, combined nevi, deep penetrating nevi, ancient nevi, desmoplastic nevi, balloon cell nevi and proliferation nodules of congenital nevi. We report our experience managing patients with these problematic tumors and discuss our approaches to determining the true location of lesional cells in sentinel nodes.

Cochran AJ, Binder S, Morton DL. The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions.

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