Presented in part at the 68th annual meeting of American Academy Dermatology, Miami, FL, USA, March 4–10, 2010.
Cutaneous involvement by colonic extranodal NK/T-cell lymphoma mimicking mycosis fungoides: a case report*
Article first published online: 23 AUG 2011
Copyright © 2011 John Wiley & Sons A/S
Journal of Cutaneous Pathology
Volume 38, Issue 12, pages 1004–1008, December 2011
How to Cite
Sitthinamsuwan, P., Pongpruttipan, T., Bunyaratavej, S., Karoopongse, E., Kummalue, T. and Sukpanichnant, S. (2011), Cutaneous involvement by colonic extranodal NK/T-cell lymphoma mimicking mycosis fungoides: a case report. Journal of Cutaneous Pathology, 38: 1004–1008. doi: 10.1111/j.1600-0560.2011.01758.x
- Issue published online: 3 NOV 2011
- Article first published online: 23 AUG 2011
- Accepted for publication April 17, 2011
- cutaneous lymphoma;
- cytotoxic T-cell lymphoma;
- Epstein-Barr virus;
- extranodal NK/T-cell lymphoma;
- mycosis fungoides
We report a 51-year-old woman with cutaneous involvement by extranodal NK/T-cell lymphoma (TCL) of the colon that microscopically mimicked mycosis fungoides (MF). She had a history of fever of unknown origin for 2 months and then developed multiple erythematous papules on her trunk and extremities. A skin biopsy revealed superficial infiltration by atypical small to medium-sized lymphocytes with epidermotropism and Pautrier collections. Immunohistochemical studies showed expression of CD3 and TIA-1 with lack of expression (double negative) of CD4 and CD8. Initially, we reported the diagnosis as MF, cytotoxic variant. Thereafter, computerized tomography scan incidentally identified a colonic mass. A colonic biopsy revealed infiltration of atypical lymphoid cells with the same morphology and immunophenotype as those found in the skin. Additionally, CD56 and Epstein-Barr virus-encoded RNA in situ hybridization in both skin and colonic biopsies were diffusely positive. Thus, extranodal NK/TCL was diagnosed. Delta T-cell receptor (TCR) gene rearrangement was documented in the skin biopsy by polyacrylamide gel electrophoresis and fluorescence capillary gel electrophoresis methods. There was no TCR gene rearrangement detected in the colonic biopsy. Unfortunately, the patient died within 2 months of diagnosis.
Sitthinamsuwan P, Pongpruttipan T, Bunyaratavej S, Karoopongse E, Kummalue T, Sukpanichnant S. Cutaneous involvement by colonic extranodal NK/T-cell lymphoma mimicking mycosis fungoides: a case report.