Hybrid schwannoma/perineurioma: a report of two cases including a possible radiation-induced case
Article first published online: 12 NOV 2011
Copyright © 2011 John Wiley & Sons A/S
Journal of Cutaneous Pathology
Volume 39, Issue 1, pages 56–62, January 2012
How to Cite
Ohata, C., Imai, N., Hinogami, H., Akamatsu, K. and Sumimura, Y. (2012), Hybrid schwannoma/perineurioma: a report of two cases including a possible radiation-induced case. Journal of Cutaneous Pathology, 39: 56–62. doi: 10.1111/j.1600-0560.2011.01805.x
- Issue published online: 27 DEC 2011
- Article first published online: 12 NOV 2011
- Accepted for publication September 8, 2011
- hybrid schwannoma/perineurioma;
Hybrid schwannoma/perineurioma represents a recently characterized dermal or subdermal tumor showing schwannian cytomorphology and a perineurioma-like architecture composed of an admixture of both cell types. We report two additional cases of hybrid schwannoma/ perineurioma, one of which occurred after irradiation. Patient 1 was that of a 33-year-old man presented with a 2.8-cm dermal tumor on his left lower leg. Patient 2 was that of an 89-year-old woman with a history of uterine carcinoma treated by surgery and radiation therapy at the age of 35. She presented with a 1.2 × 1.0 cm dermal tumor on her left mons pubis with multiple coincidental basal-cell carcinomas around it. Both tumors were microscopically well circumscribed but unencapsulated and situated in the dermis and adipose tissue and showed a vague storiform and lamellar pattern. Cytologically, both tumors contained two-cell populations, i.e. spindled cells with plump nuclei, which were positive for S-100 protein and negative for epithelial membrane antigen (EMA), claudin-1 and CD34, as well as cells with very slender nuclei and elongated cytoplasmic processes, which were negative for S-100 protein yet expressed EMA, claudin-1 and CD34. Claudin-1 was a better marker to highlight cells with very slender nuclei than EMA. Both tumors lacked expression of neurofilament.
Ohata C, Imai N, Hinogami H, Akamatsu K and Sumimura Y. Hybrid schwannoma/perineurioma: a report of two cases including a possible radiation-induced case.