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Cutaneous myoepithelioma arising within hidradenoma of the scalp

Authors

  • Kiran Jakate,

    1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
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  • Kevin Wong,

    1. Department of General Surgery, The Scarborough Hospital, Toronto, Ontario Canada
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  • Jane Sirbovan,

    1. Department of Pathology, The Scarborough Hospital, Toronto, Ontario Canada
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  • Wedad Hanna

    Corresponding author
    1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    2. Department of Anatomical Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
      Dr Wedad Hanna, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room E4 32, Toronto, ON M4N 3M5, Canada
      Tel.: +416 480 6100 ext. 3565
      Fax: +416 480 4271
      e-mail: wedad.hanna@sunnybrook.ca
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Dr Wedad Hanna, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room E4 32, Toronto, ON M4N 3M5, Canada
Tel.: +416 480 6100 ext. 3565
Fax: +416 480 4271
e-mail: wedad.hanna@sunnybrook.ca

Abstract

A 62-year-old man presented with a 2-year history of a 2-cm cystic mass involving his occiput. There had been recent enlargement, and the clinical impression was that of a pilar cyst. Histopathological sections showed a partially dermal solid and cystic proliferation. The tumor contained areas of glandular differentiation with cuboidal to columnar cells lining luminal and cystic spaces. A concurrent spindle cell proliferation was seen interspersed between glands and also formed broad, cellular sheets of cells. The stroma was sclerotic and without chondroid or myxoid elements. Immunohistochemistry showed that the spindled cells expressed S100 protein, cytokeratin and smooth muscle myosin. The immunohistochemical profile and the relationship with ductal elements supported myoepithelial differentiation. The proliferation warranted the diagnosis of myoepithelioma arising from a hidradenoma, which to our knowledge has not been previously described. In addition to discussing this case, we provide a brief review of epithelial–myoepithelial neoplasms encountered in the skin.

Jakate K, Wong K, Sirbovan J, Hanna W. Cutaneous myoepithelioma arising within hidradenoma of the scalp.

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