Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review

Authors


Shane Meehan, MD, Department of Dermatopathology, New York University, 530 First Ave Suite 7J, Dermatopathology Section, New York, New York 10016, USA
Tel: +212 263 7250
Fax: +212684 2991
e-mail: Shane.Meehan@nyumc.org

Abstract

Demonstration of T-cell receptor gene monoclonality often plays an important role in the diagnosis of T-cell lymphoma. When a test to detect monoclonality is performed on whole tissue sections, the presence of a reactive lymphocyte population may reduce sensitivity. This may be especially true for early or borderline cases of lymphoma. Microdissection techniques may be utilized to more readily identify a clonal population of lymphocytes. Subcutaneous panniculitis-like T-cell lymphoma represents a cutaneous lymphoid neoplasm whose clinical course may vary from an indolent, waxing and waning course to an aggressive course resulting in death. We report the first case of a microdissection technique used to facilitate diagnosing a case of subcutaneous panniculitis-like T-cell lympoma.

Hoffman D, Chaffins M, Cankovic M, Maeda K, Meehan S. Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review.

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