Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation

Authors


Ruifeng Guo, MD, PhD,

Department of Pathology,

University of Oklahoma Health Sciences Center,

Oklahoma City, OK, USA

Tel: 405 271 2451

Fax: 405 271 2437

e-mail: ruifeng-guo@ouhsc.edu

Abstract

Sinonasal non-keratinizing squamous cell carcinoma (SCC), previously designated as transitional cell carcinoma or cylindrical cell carcinoma, is an uncommon malignant neoplasm with distinct histopathological features, considered to be a low-grade malignancy that usually occurs in elderly patients. Extensive local invasion is uncommon. Here we report a case of 90-year-old woman whose original presentation was as erythematous nasal skin nodules, biopsy of which showed a dermal tumor with features of sinonasal non-keratinizing SCC. No epidermal dysplasia was present. A subsequent computed tomography scan confirmed the presence of an endophytic tumor on the nasal sidewall. The initial presentation of sinonasal non-keratinizing SCC as a skin lesion is previously unreported to our knowledge. Diagnosis in this context requires accurate evaluation of the histopathology as well as a comprehensive knowledge of pathology specific to this anatomic location.

Ancillary