Treatment of Therapy-Resistant Acute Myeloid Leukaemia with 7 and 8 Cytostatics
Article first published online: 24 APR 2009
© Munksgaard 1975
Scandinavian Journal of Haematology
Volume 14, Issue 1, pages 35–41, March 1975
How to Cite
Brincker, H. (1975), Treatment of Therapy-Resistant Acute Myeloid Leukaemia with 7 and 8 Cytostatics. Scandinavian Journal of Haematology, 14: 35–41. doi: 10.1111/j.1600-0609.1975.tb00291.x
- Issue published online: 24 APR 2009
- Article first published online: 24 APR 2009
- Accepted for publication December 6, 1974.
16 courses of an 8-drug regimen including daunomycin, vincristine, cytosinearabinoside, thioguanine, methotrexate, cyclophosphamide, prednisolone and hydroxyurea, and 12 courses of a 7-drug regimen including the same drugs minus hydroxyurea were administered in 16 otherwise therapy-resistant cases of acute myeloid leukaemia. In spite of a significant and rapid reduction of the leukaemic cell-mass in all the cases treated, only two brief minimal remissions were obtained. The main toxic effect was myelosuppression. However, the treatment was associated with a high frequency of mucosal ulcerations of the oesophagus and stomach, and it cannot be excluded that the latter complication may be drug-related.