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Keywords:

  • hepatosplenic γδ T-cell lymphoma;
  • transient response to Fludarabine and Alemtuzumab

Abstract:  Hepatosplenic γδ T-cell lymphoma is a rare, usually fatal lymphoma and available literature on management is sparse. Allografting is probably the only curative option. We describe a further case with a dramatic, though transient response to Fludarabine and Alemtuzumab combination, following a failure of conventional chemotherapy. Given the dreadful prognosis with conventional chemotherapy, it is a regimen worth pursuing as a disease reduction strategy prior to allograft where appropriate.