Get access

A case of hepatosplenic γδ T-cell lymphoma with a transient response to Fludarabine and Alemtuzumab


S. Mittal, Department of Clinical Haematology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
Tel: +44 (0)1224 553394
Fax: +44 (0)1224 550714


Abstract:  Hepatosplenic γδ T-cell lymphoma is a rare, usually fatal lymphoma and available literature on management is sparse. Allografting is probably the only curative option. We describe a further case with a dramatic, though transient response to Fludarabine and Alemtuzumab combination, following a failure of conventional chemotherapy. Given the dreadful prognosis with conventional chemotherapy, it is a regimen worth pursuing as a disease reduction strategy prior to allograft where appropriate.