Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene

Authors


Junko Takita, MD, PhD, Department of Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-8655 Tokyo, Japan. Tel.: +81 (3) 3815 5411 (Ex 33462); Fax: +81 (3) 3816 4108; e-mail jtakita-tky@umin.ac.jp

Abstract

Mixed-lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy-related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL-AF4 fusion transcript. MLL-AF4 is derived from t(4;11)(q21:q23) and occurs exclusively in B-cell lineage leukemia. To our knowledge, MLL-AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL-AF4-associated leukemia.

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