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Haematological reference values in Spanish adolescents: the AVENA study

Authors

  • Javier Romeo,

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
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  • Julia Wärnberg,

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
    2. Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden
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  • Sonia Gómez-Martínez,

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
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  • Ligia E. Díaz,

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
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  • Luis A. Moreno,

    1. Growth, Exercise, Nutrition and Development (GENUD) Research Group, School of Health Sciences, University of Zaragoza, Zaragoza, Spain
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  • Manuel J. Castillo,

    1. Physiology Department, School of Medicine, University of Granada, Granada, Spain
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  • Carlos Redondo,

    1. Pediatrics Department, University of Cantrabria, Cantrabria, Spain
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  • Juan C. Baraza,

    1. Department of Physiology, University of Murcia, Murcia, Spain
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  • Ricardo Sola,

    1. Unit of Haematology, University Hospital San Cecilio, Granada, Spain
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  • Salvador Zamora,

    1. Department of Physiology, University of Murcia, Murcia, Spain
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  • Ascensión Marcos,

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
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  • on behalf of the AVENA group

    1. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Instituto del Frío, Spanish National Research Council (CSIC), Madrid, Spain
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Dr. Javier Romeo Marin, Ph.D. Immunonutrition Research Group, Department of Metabolism and Nutrition, Instituto del Frío, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais, 10. 28040 Madrid, Spain. Tel: +34 915445607; Fax: + 34 91 5493627; e-mail: jromeo@if.csic.es

Abstract

Objectives:  To provide reference values for haematological indices in Spanish adolescents according to age and gender.

Methods:  A cross sectional study conducted in five Spanish cities was performed. Blood was drawn from a representative sample of 581 adolescents with age ranging from 13 to 17–18.5 yr. Age- and gender-specific means, standard deviations and percentiles were determined for the following parameters: total red blood cell counts (RBC), haemoglobin concentration (Hb), haematocrit percentage (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red cell distribution width and total white blood cell (WBC) counts as well as counts and percentage of neutrophils, lymphocytes, monocytes, eosinophils and basophils; platelet count (PLT), mean platelet volume and plateletcrit percentage.

Results:  Younger male subjects presented lower RBC, Hb, Hct and MCV means that their older counterpart. By contrast these differences were not observed in female subjects. As expected, RBC, Hb and Hct mean values in males were found significantly higher than in girls for all studied age groups. No significant differences were observed in WBC by age and gender. PLT values gradually decreased with age, except for females aged 17–18.5 yr.

Conclusion:  The present study provides reference data on the distribution of haematological indices of Spanish adolescents. These data can be useful biomarkers of the nutritional status in adolescents.

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