Elevated serum parathormone levels are associated with myocardial iron overload in patients with β-thalassaemia major
Article first published online: 10 SEP 2009
© 2009 John Wiley & Sons A/S
European Journal of Haematology
Volume 84, Issue 1, pages 64–71, January 2010
How to Cite
Dimitriadou, M., Christoforidis, A., Economou, M., Tsatra, I., Vlachaki, E., Fidani, L., Katzos, G. and Athanassiou-Metaxa, M. (2010), Elevated serum parathormone levels are associated with myocardial iron overload in patients with β-thalassaemia major. European Journal of Haematology, 84: 64–71. doi: 10.1111/j.1600-0609.2009.01349.x
- Issue published online: 11 DEC 2009
- Article first published online: 10 SEP 2009
- Accepted for publication 6 September 2009
- vitamin D;
- heart, iron overload
Objectives: Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with β-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with β-thalassaemia major.
Methods: In 62 patients (29 M and 33 F, mean age: 22.79 ± 6.18 yr) with β-thalassaemia major levels of intact parathormone (iPTH) and vitamin D metabolites [25(ΟH)D3 and 1,25(ΟH)2D3] were measured in serum. Additionally, estimation of myocardial iron content was performed by magnetic resonance imaging, whereas mean serum ferritin concentrations were calculated for 1 yr prior to the study.
Results: Results showed markedly decreased levels of serum 25(OH)D3 in 37 patients (60%), whereas 7 patients (11%) had borderline 25(OH)D3 levels (between 50 and 75 nmol/L). Serum iPTH levels were significantly higher in patients having increased myocardial iron compared to those having normal myocardial iron (44.04 ± 22.09 pg/mL vs. 31.39 ± 14.30 pg/mL, P = 0.017). Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron.