Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma
Article first published online: 11 NOV 2010
© 2010 John Wiley & Sons A/S
European Journal of Haematology
Volume 86, Issue 1, pages 32–37, January 2011
How to Cite
Papajík, T., Mysliveček, M., Šedová, Z., Buriánková, E., Procházka, V., Koranda, P., Raida, L., Kubová, Z., Palová, M., Kučerová, L., Flodr, P., Jarkovský, J., Dušek, L. and Indrák, K. (2011), Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma. European Journal of Haematology, 86: 32–37. doi: 10.1111/j.1600-0609.2010.01532.x
- Issue published online: 13 DEC 2010
- Article first published online: 11 NOV 2010
- Accepted manuscript online: 28 SEP 2010 02:52AM EST
- Accepted for publication 25 September 2010
- non-Hodgkin’s lymphoma;
- positron emission tomography;
- computed tomography;
- standardised uptake value
Objectives: Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (18F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin’s lymphoma (NHL). The intensity of 18F-FDG accumulation may be determined by calculating the so-called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F-FDG PET/CT in untreated patients with NHL.
Methods: One hundred and forty-nine initial staging 18F-FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined.
Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B-cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax < 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki-67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P < 0.001). The geometric mean of SUVmax in patients with Ki-67 ≤ 60 and those with Ki-67 > 60 was 8.8 and 14.3, respectively (P < 0.001).
Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki-67 values suggests that SUVmax might have a prognostic values in NHL.