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Keywords:

  • melatonin;
  • skin;
  • keratinocytes;
  • C57 BL-6 mouse

Abstract Specific binding sites for 3H-melatonin were delected in membrane fractions prepared from C57 BL-6 mouse skin, and were localized to the epidermis and the epithelial bulb of the hair follicle by in situ autoradiography. In skin organ culture, melatonin stimulated DNA synthesis by the epidermal keratinocytes at concentration 0.1-10 nM, while at ≥1 μM it inhibited tyrosinase activity. We concluded that murine skin is a target for melatonin bioregulation.