Previously known as laminin 5; for the revised nomenclature on laminins, see Aumailley et al. Matrix Biol 2005: 24: 326–332.
Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa
Article first published online: 21 MAY 2007
Volume 16, Issue 6, pages 465–467, June 2007
How to Cite
Rodeck, U., Fertala, A. and Uitto, J. (2007), Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa. Experimental Dermatology, 16: 465–467. doi: 10.1111/j.1600-0625.2007.00563.x
- Issue published online: 21 MAY 2007
- Article first published online: 21 MAY 2007
- Accepted for publication 9 March 2007
- collagen type VII;
- Epidermolysis bullosa dystrophica;
- signal transduction;
- squamous cell
Abstract: Squamous cell carcinomas in patients sufering from recessive dystrophic epidermolysis bullosa are highly invassive and frequently metastatic. Expression of a collagen VII fragement (NC1) has been described as a prerequisite for the development of this tumor form. This commentary focuses on potential molecular mechanisms by which expression of the NC1 fragment may augment anchorage-independent growth and survival of malignant keratinocytes.