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Keywords:

  • carcinoma;
  • collagen type VII;
  • Epidermolysis bullosa dystrophica;
  • signal transduction;
  • squamous cell

Abstract:  Squamous cell carcinomas in patients sufering from recessive dystrophic epidermolysis bullosa are highly invassive and frequently metastatic. Expression of a collagen VII fragement (NC1) has been described as a prerequisite for the development of this tumor form. This commentary focuses on potential molecular mechanisms by which expression of the NC1 fragment may augment anchorage-independent growth and survival of malignant keratinocytes.