Reduced CD26bright expression of peripheral blood CD8+ T-cell subsets in psoriatic patients


Rosanne G. van Lingen, Department of Dermatology, University Medical Centre St Radboud, P.O. Box 9101, NL- 6500 HB Nijmegen, The Netherlands, Tel.: +31 24 3617240, Fax: +31 24 3541184, e-mail:


Abstract:  Background:  T cells have been shown to be highly relevant in psoriasis. CD26 is a novel T-cell activation marker involved in various T-cell functions, e.g. (i) co-stimulation, (ii) migration and (iii) T-cell memory response. In particular, CD26bright peripheral blood T cells have been shown to be altered in several autoimmune diseases.

Objective:  To characterize CD26-expression of T-cell subsets in psoriatic patients compared to healthy subjects.

Methods:  Peripheral blood was obtained from 15 untreated patients with severe psoriasis and from nine healthy subjects. The presence of specific CD26-related T-cell subsets was assessed by flow cytometry.

Results:  The CD26bright expression of CD8+ lymphocytes revealed a statistically significant (P<0.05) decrease in psoriatic patients. The majority of CD4+CD26bright cells are CD45RO+, whereas the minority of CD8+CD26bright cells are CD45RO+ in both groups.

Conclusions:  The present study demonstrates that the CD8CD26bright T-cell population is markedly decreased in peripheral blood of psoriatic patients. Moreover, CD26 expression did not show a restriction to memory T cells. As CD26 is of relevance for T-cell functions, future investigations should focus on elucidating these functions in psoriasis. It is attractive to speculate that the reduction in the CD8CD26bright subpopulation may represent a biomarker for recompartimentalization of activated T cells and a reduced CD8CD26bright count may correlate with increased responsiveness to T-cell targeted treatments.