Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity


Miri Seiberg, The Johnson and Johnson Skin Research Center, CPPW, A division of Johnson and Johnson Consumer Product Companies, Skillman, NJ, USA, Tel.: 1-908-874-2325, Fax: 1-908-874-1254, e-mail: mseiber@its.jnj.com


Abstract:  Elastic fibres are essential extracellular matrix components of the skin, contributing to its resilience and elasticity. In the course of skin ageing, elastin synthesis is reduced, and elastase activity is accelerated, resulting in skin sagging and reduced skin elasticity. Our studies show that non-denatured Glycine max (soybean) extracts induced elastin promoter activity, inhibited elastase activity and protected elastic fibres from degradation by exogenous elastases in vitro. Mouse and swine skins topically treated with soybean extracts showed enhanced elastic fibre network and increased desmosine content. Elastin expression was also augmented in human skin transplanted onto SCID mice in response to soy treatment. These data suggest that non-denatured soybean extracts may be used as skin care agents to reduce the signs of skin ageing.