• 1
    Rawlings A V, Matts P J. Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005: 124: 10991110.
  • 2
    Leyden J J, Rawlings A V, eds. Skin Moisturization. New York: Macerl Dekker, 2002.
  • 3
    Mak V H W, Potts R O, Guy R H. Does hydration affect intercellular lipid organization in the Stratum corneum? Pharm Res 1991: 8: 10641065.
  • 4
    Warner R R, Myers M C, Taylor D A. Electron probe analysis of human skin: determination of the water concentration profile. J Invest Dermatol 1988: 90: 218224.
  • 5
    Rawlings A V. Trends in Stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci 2003: 25: 6395.
  • 6
    Rawlings A V, Harding C R. Moisturization and skin barrier function. Dermatol Ther 2004: 17 (Suppl. 1): 4348.
  • 7
    Loden M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003: 4: 771788.
  • 8
    Naik A, Kalia Y N, Pirot F, Guy R H. Characterization of molecular transport across human Stratum corneum in vivo. In: BronaughR L, MaibachH I, eds. Percutaneous Adsorption, 3rd edn. New York: Marcel Dekker Inc, 1999: 149175.
  • 9
    Serup J, Jemec G B E, Grove G L, eds. Handbook of Non-invasive Methods and the Skin. Boca Raton, FL: CRC Press, 2006: 329361.
  • 10
    Caspers P J, Lucassen G W, Puppels G J. Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys J 2003: 85: 572580.
  • 11
    Caspers P J, Lucassen G W, Carter E A, Bruining H A, Puppels G J. In vivo confocal Raman microspectroscopy of the skin: non-invasive determination of molecular concentration profiles. J Invest Dermatol 2001: 116: 434442.
  • 12
    Lucassen G W, Caspers P J, Puppels G J. Water content and water profiles in skin measured by FTIR and Raman spectroscopy. Proc SPIE 2000: 4162: 3945.
  • 13
    Wu J, Polefka T G. Confocal Raman microspectroscopy of Stratum corneum: a pre-clinical validation study. Int J Cosmet Sci 2008: 30: 4756.
  • 14
    Pudney P D A, Melot M, Caspers P J, Van Der Pol A, Puppels G J. An in vivo confocal Raman study of the delivery of trans-retinol to the skin. Appl Spectr 2007: 61: 804811.
  • 15
    Egawa M, Hirao T, Takahashi M. In vivo estimation of Stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Derm Venereol 2007: 87: 48.
  • 16
    Lucassen G W, Van Veen G N A, Jansen J A J. Band analysis of hydrated human skin Stratum corneum attenuated total reflectance Fourier transform infrared spectra in vivo. J Biomed Optics 1998: 3: 267280.
  • 17
    Potts R O, Guzek D B, Harris R R, McKie J E. A non-invasive, in vivo technique to quantitatively measure water concentration of the Stratum corneum using ATR IR spectroscopy. Arch Dermatol Res 1985: 277: 489495.
  • 18
    Brancaleon L, Bamberg M P, Sakamaki T, Kollias N. ATR-FTIR spectroscopy as a possible method to investigate biophysical parameters of Stratum corneum in vivo. J Invest Dermatol 2001: 116: 380386.
  • 19
    Berardesca E, Mason P, Rodrigues L et al. EEMCO guidance for the assessment of Stratum corneum hydration: electrical methods. Skin Res Technol 1997: 3: 126132.
  • 20
    Barel A, Clarys P. In vitro calibration of the capacitance method (Corneometer CM 825) and conductance method (Skicon-200) for the evaluation of the hydration state of the skin. Skin Res Technol 1997: 3: 107113.
  • 21
    Obata M, Tagami H. Electrical determination of water content and concentration profile in a simulation model of in vivo Stratum corneum. J Invest Dermatol 1989: 92: 854859.
  • 22
    Rougier A, Lotte C. Predictive approaches I. The stripping technique. In: ShahV P, MaibachH I, eds. Topical Drug Bioavailability, Bioequivalence, and Penetration. New York: Plenum, 1993: 163181.
  • 23
    Herkenne C, Alberti I, Naik A et al. In vivo methods for the assessment of topical drug bioavailability. Pharm Res 2007: 25: 87103.
  • 24
    Tagami H, Masatoshi O, Iwatsuki K, Kanamaru Y, Yamada M, Ichijo B. Evaluation of the skin surface hydration in vivo by electrical measurement. J Invest Dermatol 1980: 75: 500507.
  • 25
    Hashimoto-Kumasaka K, Takahashi K, Tagami H. Electrical measurement of the water content of the Stratum corneum in vivo and in vitro under various conditions: comparison between skin surface hygrometer and corneometer in evaluation of the skin surface hydration state. Acta Derm Venereol 1993: 73: 335339.
  • 26
    Gay C L, Guy R H, Golden G M, Mak V H W, Francoeur M L. Characterization of low-temperature (i.e., <65°C) lipid transitions in human Stratum corneum. J Invest Dermatol 1994: 103: 233239.
  • 27
    Ongpipattanakul B, Francoeur M L, Potts R O. Polymorphism in Stratum corneum lipids. Biochim Biophys Acta 1994: 1190: 115122.
  • 28
    Voegeli R, Heiland J, Doppler S, Rawlings A V, Schreier T. Efficient and simple quantification of Stratum corneum proteins on tape strippings by infrared densitometry. Skin Res Technol 2007: 13: 242251.
  • 29
    Rogiers V. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001: 14: 117128.
  • 30
    Gniadecka M, Nielsen O F, Christensen D H, Wulf H C. Structure of water, proteins, and lipids in intact human skin, hair, and nail. J Invest Dermatol 1998: 110: 393398.
  • 31
    Imokawa G, Kuno H, Kawai M. Stratum corneum lipids serve as a bound-water modulator. J Invest Dermatol 1991: 96: 845851.
  • 32
    Kasting G B, Barai N D. Equilibrium water sorption in human Stratum corneum. J Pharm Sci 2003: 92: 16241631.
  • 33
    Harding C R. The Stratum corneum: structure and function in health and disease. Dermatol Ther 2004: 17: 615.
  • 34
    Marzec E. Analysis of the dielectric properties of keratin in the α-dispersion electric field region. Med Biol Eng Comput 2001: 39: 558561.
  • 35
    Gennis R B. Biomembranes: Molecular Structure and Function. New York: Springer-Verlag Inc, 1989.
  • 36
    Elias P M. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005: 125: 183200.
  • 37
    Hellemans L, Van Der Pol A, Van Overloop L, Riggs B, Declercq L, Maes D. In vivo measurement of dynamics of water movement across the Stratum corneum after barrier disruption. J Invest Dermatol 2005: 125 (Suppl. S): A11065.
  • 38
    Bouwstra J A, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta Biomembr 2006: 1758: 20802095.
  • 39
    Fluhr J W, Feingold K R, Elias P M. Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models. Exp Dermatol 2006: 15: 483492.
  • 40
    Van Der Pol A, De Sterke J, Caspers P J. Modeling and interpretation of water concentration gradients in the Stratum corneum as measured by confocal Raman microscpectroscopy. Int J Cosm Sci. 2007: 29: 235.
  • 41
    Horii I, Nakayama Y, Obata M, Tagami H. Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol 1989: 121: 587592.