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Expression of keratins in cutaneous epithelial tumors and related disorders – distribution and clinical significance
Article first published online: 16 FEB 2011
DOI: 10.1111/j.1600-0625.2009.01006.x
© 2011 John Wiley & Sons A/S
Additional Information
How to Cite
Kurokawa, I., Takahashi, K., Moll, I. and Moll, R. (2011), Expression of keratins in cutaneous epithelial tumors and related disorders – distribution and clinical significance. Experimental Dermatology, 20: 217–228. doi: 10.1111/j.1600-0625.2009.01006.x
Publication History
- Issue published online: 16 FEB 2011
- Article first published online: 16 FEB 2011
- Accepted for publication 15 September 2009
References
- 1, , , , . Antibody to prekeratin. Decoration of tonofilament like arrays in various cells of epithelial character. Exp Cell Res 1978: 116: 429–445.
- 2, , . Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci USA 1979: 76: 2813–2817.
- 3, , , , . The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982: 31: 11–24.
- 4, , , et al. New consensus nomenclature for mammalian keratins. J Cell Biol 2006: 174: 169–174.
- 5. Intermediate filaments: a historical perspective. Exp Cell Res 2007: 313: 1981–1994.
- 6, , . The human keratins: biology and pathology. Histochem Cell Biol 2008: 129: 705–733.
- 7, , . Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol 1990: 111: 567–580.
- 8, , . The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. Differentiation 1986: 32: 101–119.
- 9, , . Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J Cell Sci 2001: 114: 2569–2575.
- 10, , , , . The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. Differentiation 2004: 72: 527–540.
- 11, , , . Hair follicle-specific keratins and their diseases. Exp Cell Res 2007: 313: 2010–2020.
- 12, , , et al. Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. J Invest Dermatol 2005: 125: 428–444.
- 13, , , , . K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J Invest Dermatol 2003: 120: 512–522.
- 14, . Genes coding for intermediate filament proteins closely related to the hagfish “thread keratins (TK)” alpha and gamma also exist in lamprey, teleosts and amphibians. Exp Cell Res 2006: 312: 1447–1462.
- 15, , . Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene 2006: 368: 37–45.
- 16, , , , , . Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. J Invest Dermatol 2005: 124: 536–544.
- 17, , . The genome of the early chordate Ciona intestinalis encodes only five cytoplasmic intermediate filament proteins including a single type I and type II keratin and a unique IF-annexin fusion protein. Gene 2004: 326: 123–129.
- 18, , , . Comprehensive analysis of keratin gene clusters in humans and rodents. Eur J Cell Biol 2004: 83: 19–26.
- 19, , . Genes coding for intermediate filament proteins: common features and unexpected differences in the genomes of humans and the teleost fish Fugu rubripes. J Cell Sci 2003: 116: 2295–2302.
- 20. Concerted gene duplications in the two keratin gene families. J Mol Evol 1988: 27: 203–211.
- 21, , , , , . Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalog. J Invest Dermatol 2007: 127: 1532–1535.
- 22, . Keratins of the human hair follicle. Int Rev Cytol 2005: 243: 1–78.
- 23, , , et al. Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress. Br J Dermatol 1998: 139: 767–775.
- 24, , , , , . Trichilemmoma: an immunohistochemical study of cytokeratins. Br J Dermatol 2003: 149: 99–104.
- 25, , . Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J Cutan Pathol 1995: 22: 518–535.
- 26, , , , , . Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc 1999: 4: 296–301.
- 27, , . Sebaceous carcinoma, trichoblastoma, and sebaceoma with features of trichoblastoma in nevus sebaceus. Am J Dermatopathol 2001: 23: 456–462.
- 28, . Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions. Am J Pathol 2008: 173: 752–761.
- 29, , , et al. A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle. J Invest Dermatol 1998: 111: 955–962.
- 30, , , , , . K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. J Invest Dermatol 2006: 126: 2377–2386.
- 31, , , et al. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. J Biol Chem 1999: 274: 19874–19884.
- 32, , , , . The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins. J Biol Chem 2001: 276: 35123–35132.
- 33
- 34, , , , , . Immunohistochemical analysis of keratin distribution in eccrine poroma. Am J Pathol 1993: 142: 231–239.
- 35, , , , , . New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma. Br J Dermatol 2008: 159: 633–645.
- 36, . Comparative cytokeratin analysis of sweat gland ducts and eccrine poromas. Arch Dermatol Res 1991: 283: 300–309.
- 37, , , et al. An immunohistochemical and histochemical study of cytokeratin, involucrin and transglutaminase in seborrhoeic keratosis. Arch Dermatol Res 1993: 285: 482–490.
- 38, . Immunohistochemical characterization of keratin expression in clear cell acanthoma. Br J Dermatol 1995: 133: 186–193.
- 39, , , et al. Keratin and filaggrin expression in keratoacanthoma. J Eur Acad Dermatol Venereol 2008: 22: 353–355.
- 40, , . Expression of keratin and involucrin in keratoacanthoma: an immunohistochemical aid to diagnosis. J Dermatol Sci 2004: 34: 115–117.
- 41, , , et al. Cytokeratin and filaggrin expression in nevus comedonicus. J Cutan Pathol 2007: 34: 338–341.
- 42, , , , . Expression of epidermal keratins and filaggrin during human fetal skin development. J Cell Biol 1985: 101: 1257–1269.
- 43, , , . Dilated pore: a case report and an immunohistochemical study of cytokeratin expression. J Dermatol 2003: 30: 556–558.
- 44, , , , , . Trichoadenoma: cytokeratin expression suggesting differentiation towards the follicular infundibulum and follicular bulge regions. Br J Dermatol 2005: 153: 1084–1086.
- 45, , , , , . Trichofolliculoma: case report with immunohistochemical study of cytokeratins. Br J Dermatol 2003: 148: 597–598.
- 46, . Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma. Br J Dermatol 1999: 140: 8–16.
- 47, , , . Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma. Am J Dermatopathol 2001: 23: 501–509.
- 48, . Merkel cells in nevus sebaceus. An immunohistochemical study. Am J Dermatopathol 1995: 17: 570–579.
- 49, , . Cytokeratin analysis of pilomatrixoma: changes in cytokeratin-type expression during differentiation. J Invest Dermatol 1988: 91: 251–257.
- 50, , , , , . Expression of type I hair keratins in follicular tumours. Br J Dermatol 2001: 144: 977–982.
- 51, , , , . On the regulation of hair keratin expression: lessons from studies in pilomatricomas. J Invest Dermatol 2004: 122: 1078–1083.
- 52, , . Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin. Br J Dermatol 1994: 131: 506–513.
- 53, , , et al. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge. Exp Dermatol 2009: 18: 734–737.
- 54, , , , , . Cytokeratin expression in steatocystoma multiplex. Br J Dermatol 2002: 146: 534–536.
- 55, , . Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol 1997: 19: 250–253.
- 56, , , et al. Rippled-pattern sebaceoma with an immunohistochemical study of cytokeratins. J Eur Acad Dermatol Venereol 2007: 21: 133–134.
- 57, . Cytokeratin 15 expression in neoplasms with sebaceous differentiation. J Cutan Pathol 2006: 33: 634–641.
- 58, . Rippled-pattern sebaceoma. Am J Dermatopathol 2001: 23: 437–443.
- 59, , , . Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. Am J Dermatopathol 2002: 24: 294–304.
- 60, , . Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: three distinct tumors defined by expression of keratins and human milk fat globulin 1. J Cutan Pathol 1997: 24: 249–255.
- 61, , , , . Keratinizing squamous epithelium associated with syringocystadenoma papilliferum differentiates towards infrainfundibulum: case report with immunohistochemical study of cytokeratins. J Int Med Res 2005: 33: 590–593.
- 62, , , , . An immunohistochemical and ultrastructural study of syringocystadenoma papilliferum. Br J Dermatol 2002: 147: 936–945.
- 63, . Histogenesis of mixed tumor of the skin, apocrine type: immunohistochemical study of keratin expression. Am J Dermatopathol 1997: 19: 456–461.
- 64, , . Eccrine syringofibroadenoma: a case report with analysis of cytokeratin expression. Br J Dermatol 1992: 126: 257–261.
- 65, , . Immunohistochemical analysis of cytokeratin expression in reactive eccrine syringofibroadenoma-like lesion: a comparative study with eccrine syringofibroadenoma. J Cutan Pathol 2000: 27: 164–168.Direct Link:
- 66, . Eccrine syringofibroadenoma (Mascaro). An ultrastructural and immunohistochemical study. Am J Dermatopathol 1996: 18: 207–211.
- 67, , . Eccrine syringofibroadenoma (Mascaro): an immunohistochemical study. Am J Dermatopathol 2000: 22: 171–175.
- 68, , , et al. An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies. Arch Dermatol Res 1990: 282: 383–391.
- 69, , , , , . A case report of hidroacanthoma simplex with an immunohistochemical study of cytokeratins. Int J Dermatol 2005: 44: 775–776.
- 70, , , et al. [Eccrine poroma. A clinico-pathologic and immunohistologic study with special reference to tumor cell differentiation]. Hautarzt 1991: 42: 692–699.
- 71, . Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma. J Cutan Pathol 1997: 24: 370–376.
- 72, , , , , . Papillary eccrine adenoma: immunohistochemical studies of keratin expression. J Cutan Pathol 1997: 24: 564–570.
- 73, . Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. Am J Dermatopathol 1997: 19: 154–161.
- 74, , , . Cylindroma as tumor of hair follicle origin. J Invest Dermatol 2006: 126: 1182–1184.
- 75, , , . Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation. J Cutan Pathol 1993: 20: 337–343.
- 76, , , et al. Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. J Eur Acad Dermatol Venereol 2007: 21: 121–123.
- 77, , , . Immunohistochemical analysis of cytokeratin expression in eccrine spiradenoma: similarities to the transitional portions between secretory segments and coiled ducts of eccrine glands. Br J Dermatol 1994: 131: 799–807.
- 78, . Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression. J Cutan Pathol 1997: 24: 30–36.
- 79, , , et al. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. Acta Derm Venereol 1993: 73: 286–292.
- 80, , , , , . Trichoblastoma and basal cell carcinoma are neoplasms with follicular differentiation sharing the same profile of cytokeratin intermediate filaments. Am J Dermatopathol 1997: 19: 341–350.
- 81, , , , . Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell carcinomas of the skin. Arch Dermatol Res 1989: 281: 83–88.
- 82, , , et al. Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors. Exp Dermatol 2006: 15: 742–750.
- 83, , , et al. Pinkus tumor may originate from intraepidermal eccrine ducts and proliferate in the dermis. Oncol Rep 2007: 17: 49–54.
- 84, , . Differences of expression of cytokeratin polypeptides in various epithelial skin tumors. Arch Dermatol Res 1984: 276: 349–363.
- 85, . Merkel cell hyperplasia in chronic radiation-damaged skin: its possible relationship to fibroepithelioma of Pinkus. J Cutan Pathol 1997: 24: 477–483.
- 86, , . Immunohistochemical localization of keratins and involucrin in solar keratosis and Bowen’s disease. Am J Dermatopathol 1995: 17: 151–157.
- 87, , , , . Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia. J Invest Dermatol 1991: 97: 763–770.
- 88
- 89, , , , , . HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol 2007: 16: 590–599.
- 90, , , , . An in vitro three-dimensional model of primary human cutaneous squamous cell carcinoma. Exp Dermatol 2009: 18: 849–856.
- 91, . Cells of extramammary Paget’s disease express cytokeratins different from those of epidermal cells. J Invest Dermatol 1985: 84: 3–8.
- 92, . The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget’s disease. Br J Dermatol 2000: 142: 243–247.
- 93, , , , . Merkel cell carcinoma: a clinicopathological study of 11 cases. J Eur Acad Dermatol Venereol 2005: 19: 546–551.
- 94, , , . Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 1992: 140: 427–447.
- 95, , , et al. Cytokeratin expression in trichilemmal carcinoma suggests differentiation towards follicular infundibulum. In Vivo 2006: 20: 583–585.
- 96, , , . Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity. Dermatol Surg 2003: 29: 886–889.
- 97, , , , , . Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study. J Cutan Pathol 2006: 33: 1–9.
- 98, , , , . Cutaneous horn can be a clinical manifestation of underlying sebaceous carcinoma. Br J Dermatol 2007: 156: 180–182.
- 99
- 100, , , et al. Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma. Oncol Rep 2006: 16: 473–477.
- 101, . Immunohistochemical observation of cytokeratins in keratinous cysts including plantar epidermoid cyst. J Cutan Pathol 1999: 26: 424–429.
- 102, , , et al. Filaggrin expression and the pathogenesis of epidermal cysts. Br J Dermatol 2007: 157: 415–416.
- 103, , , et al. Cutaneous dermoid cyst: cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland. Oncol Rep 2006: 16: 295–299.
- 104, , , et al. Cytokeratin expression in pilonidal sinus. Br J Dermatol 2002: 146: 409–413.
- 105, , , et al. Cytokeratin, filaggrin, and p63 expression in reepithelialization during human cutaneous wound healing. Wound Repair Regen 2006: 14: 38–45.
- 106, , , . Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol 1996: 132: 381–397.
- 107, , , . Keratins and the keratinocyte activation cycle. J Invest Dermatol 2001: 116: 633–640.
- 108, , , , , . Immunohistochemical study of cytokeratins in hidradenitis suppurativa (acne inversa). J Int Med Res 2002: 30: 131–136.
- 109, , , , , . Cytokeratin expression in squamous cell carcinoma arising from hidradenitis suppurativa (acne inversa). J Cutan Pathol 2007: 34: 675–678.
- 110, , , . Keratin expression in pilosebaceous epithelia in truncal skin of acne patients. Br J Dermatol 1996: 134: 247–256.
- 111, , , . Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrhoeic and acne skin. J Invest Dermatol 1988: 91: 566–571.
- 112, , . Diseases of epidermal keratins and their linker proteins. Exp Cell Res 2007: 313: 1995–2009.
- 113, . Keratin function in skin epithelia: a broadening palette with surprising shades. Curr Opin Cell Biol 2007: 19: 13–23.
- 114, , , , . Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo. Eur J Cell Biol 2004: 83: 735–746.
- 115, , . Structural and regulatory functions of keratins. Exp Cell Res 2007: 313: 2021–2032.
- 116, . Disorders of keratinisation: from rare to common genetic diseases of skin and other epithelial tissues. Ulster Med J 2007: 76: 72–82.
- 117, . Keratins and skin disorders. J Pathol 2004: 204: 355–366.
- 118, , , et al. The genetic basis of pachyonychia congenita. J Investig Dermatol Symp Proc 2005: 10: 21–30.
- 119, , , et al. Clinical and pathological features of pachyonychia congenita. J Investig Dermatol Symp Proc 2005: 10: 3–17.
- 120, . The quest for the function of simple epithelial keratins. Bioessays 2003: 25: 748–758.
- 121, , , , . Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology 2007: 46: 1639–1649.
- 122, . Intermediate filaments and stress. Exp Cell Res 2007: 313: 2244–2254.
- 123, , . Using transgenic models to study the pathogenesis of keratin-based inherited skin diseases. J Dermatol Sci 1999: 21: 73–95.

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