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Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation

  1. Ji-Young Bae1,
  2. Jung-Suk Choi1,
  3. Sang-Wook Kang1,
  4. Yong-Jin Lee2,
  5. Jinseu Park3,
  6. Young-Hee Kang1

Article first published online: 25 JAN 2010

DOI: 10.1111/j.1600-0625.2009.01044.x

Issue

Experimental Dermatology

Experimental Dermatology

Volume 19, Issue 8, pages e182–e190, August 2010

Additional Information

How to Cite

Bae, J.-Y., Choi, J.-S., Kang, S.-W., Lee, Y.-J., Park, J. and Kang, Y.-H. (2010), Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Experimental Dermatology, 19: e182–e190. doi: 10.1111/j.1600-0625.2009.01044.x

Author Information

  1. 1

    Department of Food and Nutrition, Hallym University, Chuncheon, Korea

  2. 2

    Chuncheon Bioindustry Foundation, Chuncheon, Korea

  3. 3

    Department of Biomedical Science, Hallym University, Chuncheon, Korea

*Young-Hee Kang, PhD, Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do, 200-702, Korea, Tel.: 82-33-248-2132, Fax: 82-33-254-1475, e-mail: yhkang@hallym.ac.kr

Publication History

  1. Issue published online: 21 JUL 2010
  2. Article first published online: 25 JAN 2010
  3. Accepted for publication 20 November 2009

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Keywords:

  • ellagic acid;
  • inflammation;
  • photoageing;
  • skin;
  • wrinkle

Please cite this paper as: Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Experimental Dermatology 2010; 19: e182–e190.

Abstract:  Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. This study examined photoprotective effects of ellagic acid on collagen breakdown and inflammatory responses in UV (ultraviolet)-B irradiated human skin cells and hairless mice. Ellagic acid attenuated the UV-B-induced toxicity of HaCaT keratinocytes and human dermal fibroblasts. Non-toxic ellagic acid markedly prevented collagen degradation by blocking matrix metalloproteinase production in UV-B-exposed fibroblasts. Anti-wrinkle activity of ellagic acid was further investigated in hairless mice exposed to UV-B, in which it attenuated UV-B-triggered skin wrinkle formation and epidermal thickening. Topical application of 10 μmol/l ellagic acid diminished production of pro-inflammatory cytokines IL-1β and IL-6, and blocked infiltration of inflammatory macrophages in the integuments of SKH-1 hairless mice exposed to UV-B for 8 weeks. In addition, this compound mitigated inflammatory intracellular cell adhesion molecule-1 expression in UV-B-irradiated keratinocytes and photoaged mouse epidermis. These results demonstrate that ellagic acid prevented collagen destruction and inflammatory responses caused by UV-B. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting skin wrinkle and inflammation associated with chronic UV exposure leading to photoageing.

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