Is there a ‘gut–brain–skin axis’?

Authors

  • Petra Arck,

    1. Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany
    2. Brain-Body Institute, McMaster University and St Joseph’s Healthcare, Hamilton, Canada
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  • Bori Handjiski,

    1. Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany
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  • Evelin Hagen,

    1. Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany
    2. Brain-Body Institute, McMaster University and St Joseph’s Healthcare, Hamilton, Canada
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  • Maike Pincus,

    1. Department of Pediatrics, Division of Pneumology and Immunology, Charité University Medical Center, Berlin, Germany
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  • Christian Bruenahl,

    1. Brain-Body Institute, McMaster University and St Joseph’s Healthcare, Hamilton, Canada
    2. Department of Pediatrics, Division of Pneumology and Immunology, Charité University Medical Center, Berlin, Germany
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  • John Bienenstock,

    1. Brain-Body Institute, McMaster University and St Joseph’s Healthcare, Hamilton, Canada
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  • Ralf Paus

    1. Department of Dermatology, University of Luebeck, Luebeck, Germany
    2. School of Translational Medicine, University of Manchester, Manchester, UK
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Petra Arck, Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany, Tel.: +49 30 450 553873, Fax: +49 30 450553946, e-mail: petra.arck@charite.de

Abstract

Please cite this paper as: Is there a ‘gut–brain–skin axis’? Experimental Dermatology 2010; 19: 401–405.

Abstract:  Emerging evidence arising from interdisciplinary research supports the occurrence of communication axes between organs, such as the brain–gut or brain–skin axis. The latter is employed in response to stress challenge, along which neurogenic skin inflammation and hair growth inhibition is mediated. We now show that ingestion of a Lactobacillus strain in mice dampens stress-induced neurogenic skin inflammation and the hair growth inhibition. In conclusion, we are introducing a hypothesis, encouraged by our pilot observations and resting upon published prior evidence from the literature, which amalgamates previously proposed partial concepts into a new, unifying model, i.e. the gut–brain–skin axis. This concept suggests that modulation of the microbiome by deployment of probiotics can not only greatly reduce stress-induced neurogenic skin inflammation but even affect a very complex cutaneous phenomenon of (mini-) organ transformation, i.e. hair follicle cycling. These observations raise the intriguing prospect that feeding of just the right kind of bacteria can exert profound beneficial effects on skin homoeostasis, skin inflammation, hair growth and peripheral tissue responses to perceived stress.

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