These authors contributed equally to this work.
Letter to the Editor
Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified
Article first published online: 18 APR 2012
© 2012 John Wiley & Sons A/S
Volume 21, Issue 5, pages 390–393, May 2012
How to Cite
Redler, S., Tazi-Ahnini, R., Drichel, D., Birch, M. P., Brockschmidt, F. F., Dobson, K., Giehl, K. A., Refke, M., Kluck, N., Kruse, R., Lutz, G., Wolff, H., Böhm, M., Becker, T., Nöthen, M. M., Betz, R. C. and Messenger, A. (2012), Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified. Experimental Dermatology, 21: 390–393. doi: 10.1111/j.1600-0625.2012.01469.x
- Issue published online: 18 APR 2012
- Article first published online: 18 APR 2012
- Accepted manuscript online: 14 FEB 2012 10:26AM EST
- Accepted for publication 8 February 2012
- association study;
- female pattern hair loss;
- sex steroid hormone receptors
Abstract: Female pattern hair loss (FPHL) is a common disorder with a complex mode of inheritance. Although understanding of its etiopathogenesis is incomplete, an interaction between genetic and hormonal factors is assumed to be important. The involvement of an androgen-dependent pathway and sex steroid hormones is the most likely hypothesis. We therefore selected a total of 21 variants from the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2, the sex steroid hormone receptors ESR1, ESR2 (oestrogen receptor) and PGR (progesterone receptor) and genotyped these in a case–control sample of 198 patients (145 UK; 53 German patients) and 329 controls (179 UK; 150 German). None of these variants showed any significant association, either in the overall UK and German samples or in the subgroup analyses. In summary, the present results, while based on a limited selection of gene variants, do not point to the involvement of SRD5A1, SRD5A2, ESR1, ESR2 or PGR in FPHL.