These authors share senior authorship.
Letter to the Editor
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides
Article first published online: 10 JUL 2012
© 2012 John Wiley & Sons A/S
Volume 21, Issue 8, pages 632–634, August 2012
How to Cite
Benner, M. F., Ballabio, E., van Kester, M. S., Saunders, N. J., Vermeer, M. H., Willemze, R., Lawrie, C. H. and Tensen, C. P. (2012), Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides. Experimental Dermatology, 21: 632–634. doi: 10.1111/j.1600-0625.2012.01548.x
- Issue published online: 10 JUL 2012
- Article first published online: 10 JUL 2012
- Accepted manuscript online: 7 JUN 2012 12:50PM EST
- Manuscript Accepted: 4 JUN 2012
- miRNA microarray;
- mycosis fungoides;
- primary cutaneous anaplastic large cell lymphoma;
The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoides (MF). We identified 13 differentially expressed miRNAs between C-ALCL and BID. The up-regulation of miR-155, miR-27b, miR-30c and miR-29b in C-ALCL was validated by miRNA-Q-PCR on independent study groups. Additionally, the miRNA expression profiles of C-ALCL were compared with those of tumor-stage MF. Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL. This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas.