This research was supported by grants AIl3013 and DK39672 from the National Institutes of Health, and a grant from the Ministry of Science. Education and Culture of Japan.
Dendritic cells in the T-cell areas of lymphoid organs
Version of Record online: 28 APR 2006
Volume 156, Issue 1, pages 25–37, April 1997
How to Cite
Steinman, R. M., Pack, M. and Inaba, K. (1997), Dendritic cells in the T-cell areas of lymphoid organs. Immunological Reviews, 156: 25–37. doi: 10.1111/j.1600-065X.1997.tb00956.x
- Issue online: 28 APR 2006
- Version of Record online: 28 APR 2006
Summary: Substantial numbers of dendritic cells (DCs) are found in the T-cell areas of peripheral lymphoid organs such as the spleen, lymph node and Peyer's patch. By electron microscopy these DCs (also called interdigitating cells) form a network through which T cells continually recirculate. The cytological features of DCs in the T-cell areas, as well as a number of markers detected with monoclonal antibodies, are similar to mature DCs that develop from other sites such as skin and bone marrow. Some markers that are expressed in abundance are: MHC II and the associated invariant chain, accessory molecules such as CD40 and CD86, a multilectin receptor for antigen presentation called DEC-205, the integrin CD11c, several antigens within the endocytic system that are detected by monoclonal anti-bodies but are as yet uncharacterized at the molecular level, and, in the human system, molecules termed Sl00b, CD83 and p55. DCs in the periphery can pick up antigens and migrate to the T-cell areas to initiate immunity However, there are new observations that DCs within the T-cell areas also express high levels of self-antigens and functional fas-ligand capable of Inducing CD4+ T-cell death. We speculate that there are at least 2 sets of DCs in the T-cell areas, a migratory myeloid pathway that brings in antigens from the periphery and induces immunity, and a more resident lymphoid pathway that presents self-antigens and maintains tolerance.