Immunological reconstitution following bone marrow transplantation

Authors

  • Robertson Parkman,

    Corresponding author
    1. Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital, Los Angeles, Los Angeles, California, USA.
    2. Departments of Pediatrics and Microbiology, University of Southern California School of Medicine, Los Angeles, California, USA.
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  • Kenneth I. Weinberg

    1. Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital, Los Angeles, Los Angeles, California, USA.
    2. Departments of Pediatrics and Microbiology, University of Southern California School of Medicine, Los Angeles, California, USA.
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Robertson Parkman Division of Research Immunology/Bone Marrow Transplantation Children's Hospital, Los Angeles 4650 Sunset Boulevard MS #62 Los Angeles CA 90027 USA Fax: 213-660-1904 e-mail: rparlanan%smtpgate@chlais.usc.edu

Abstract

Summary: The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft-versus-host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen-specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.

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