Immunological reconstitution following bone marrow transplantation
Article first published online: 28 APR 2006
Volume 157, Issue 1, pages 73–78, June 1997
How to Cite
Parkman, R. and Weinberg, K. I. (1997), Immunological reconstitution following bone marrow transplantation. Immunological Reviews, 157: 73–78. doi: 10.1111/j.1600-065X.1997.tb00975.x
- Issue published online: 28 APR 2006
- Article first published online: 28 APR 2006
Summary: The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft-versus-host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen-specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.