Induction of CD8+ T cells using heterologous prime-boost immunisation strategies
Article first published online: 28 APR 2006
Volume 170, Issue 1, pages 29–38, August 1999
How to Cite
Schneider, J., Gilbert, S. C., Hannan, C. M., Dégano, P., Prieur, E., Sheu, E. G., Plebanski, M. and Hill, A. V. S. (1999), Induction of CD8+ T cells using heterologous prime-boost immunisation strategies. Immunological Reviews, 170: 29–38. doi: 10.1111/j.1600-065X.1999.tb01326.x
- Issue published online: 28 APR 2006
- Article first published online: 28 APR 2006
Summary: One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce higb protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria, A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8’ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.