KIR and disease: a model system or system of models?
Article first published online: 7 NOV 2006
Volume 214, Issue 1, pages 186–201, December 2006
How to Cite
Khakoo, S. I. and Carrington, M. (2006), KIR and disease: a model system or system of models?. Immunological Reviews, 214: 186–201. doi: 10.1111/j.1600-065X.2006.00459.x
- Issue published online: 7 NOV 2006
- Article first published online: 7 NOV 2006
- KIR–HLA interactions;
- natural killer cells;
- haplotypic diversity;
- genetic association studies
Summary: The discovery of an unexpected level of diversity among the killer cell immunoglobulin-like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.