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To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils
Article first published online: 10 SEP 2007
DOI: 10.1111/j.1600-065X.2007.00544.x
2007 Blackwell Munksgaard
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How to Cite
Allen, L.-A. H. and McCaffrey, R. L. (2007), To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils. Immunological Reviews, 219: 103–117. doi: 10.1111/j.1600-065X.2007.00544.x
Publication History
- Issue published online: 10 SEP 2007
- Article first published online: 10 SEP 2007
- Abstract
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Keywords:
- phagocytosis;
- phagosome maturation;
- respiratory burst;
- superoxide;
- degranulation;
- apoptosis
Summary: Neutrophils accumulate rapidly at sites of infection, and the ability of these cells to phagocytose and kill microorganisms is an essential component of the innate immune response. Relatively few microbial pathogens are able to evade neutrophil killing. Herein, we describe the novel strategies used by Helicobacter pylori and Francisella tularensis to disrupt neutrophil function, with a focus on assembly and activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.