* Present Address: Division of Infectious Diseases, Department of Medicine, New York University, School of Medicine, New York, 10016 NY, USA.
Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis
Article first published online: 19 SEP 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Special Issue: Immunology of Emerging Infections
Volume 225, Issue 1, pages 244–255, October 2008
How to Cite
Kirimanjeswara, G. S., Olmos, S., Bakshi, C. S. and Metzger, D. W. (2008), Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis. Immunological Reviews, 225: 244–255. doi: 10.1111/j.1600-065X.2008.00689.x
- Issue published online: 19 SEP 2008
- Article first published online: 19 SEP 2008
- Fc receptors;
Summary: Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries. The correlates of protective immunity against this intracellular bacterium are not known, and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell-derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.