• Please log in or register to access this feature.

Hantavirus-induced immunity in rodent reservoirs and humans

  1. Günther Schönrich1,
  2. Andreas Rang1,
  3. Nina Lütteke1,
  4. Martin J. Raftery1,
  5. Nathalie Charbonnel2,
  6. Rainer G. Ulrich3

Article first published online: 19 SEP 2008

DOI: 10.1111/j.1600-065X.2008.00694.x

Issue

Immunological Reviews

Immunological Reviews

Special Issue: Immunology of Emerging Infections

Volume 225, Issue 1, pages 163–189, October 2008

Additional Information

How to Cite

Schönrich, G., Rang, A., Lütteke, N., Raftery, M. J., Charbonnel, N. and Ulrich, R. G. (2008), Hantavirus-induced immunity in rodent reservoirs and humans. Immunological Reviews, 225: 163–189. doi: 10.1111/j.1600-065X.2008.00694.x

Author Information

  1. 1

    Institute of Virology, Charité– Universitätsmedizin Berlin, Berlin, Germany.

  2. 2

    Centre de biologie et de Gestion des populations (CBGP), INRA-EFPA, Campus international de Baillarguet, Montferrier sur Lez, France.

  3. 3

    Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute for Novel and Emerging Infectious Diseases, Greifswald – Insel Riems, Germany.

* Dr. Rainer G. Ulrich Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health OIE Collaborating Centre for Zoonoses in Europe Institute for Novel and Emerging Infectious Diseases, Südufer 10, D-17493 Greifswald - Insel Riems, Germany Tel.: +49 38351 7159 Fax: +49 38351 7192 e-mail: rainer.ulrich@fli.bund.de

Publication History

  1. Issue published online: 19 SEP 2008
  2. Article first published online: 19 SEP 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (786K)

Keywords:

  • viral hemorrhagic fever;
  • hantavirus cardiopulmonary syndrome;
  • hantaviruses;
  • rodent reservoir;
  • transmission;
  • cell-mediated pathogenesis;
  • immunopathogenesis

Summary: Hantaviruses are predominantly rodent-borne pathogens, although recently novel shrew-associated hantaviruses were found. Within natural reservoir hosts, hantairuses do not cause obvious pathogenetic effects; transmission to humans, however, can lead to hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome, depending on the virus species involved. This review is focussed on the recent knowledge on hantavirus-induced immune responses in rodent reservoirs and humans and their impact on susceptibility, transmission, and outcome of hantavirus infections. In addition, this review incorporates a discussion on the potential role of direct cell-virus interactions in the pathogenesis of hantavirus infections in humans. Finally, questions for further research efforts on the immune responses in potential hantavirus reservoir hosts and humans are summarized.

View Full Article (HTML) Get PDF (786K)