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DAP10- and DAP12-associated receptors in innate immunity


  • Lewis L. Lanier

    1. Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA, USA.
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Lewis L. Lanier
Department of Microbiology and Immunology and the Cancer Research Institute
University of California San Francisco
513 Parnassus Avenue, Box 0414
HSE 1001G
San Francisco, CA 94143-0414, USA
Tel.: +1 415 514 0829
Fax: +1 415 502 8424


Summary:  The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.