Unique properties of memory B cells of different isotypes

Authors

  • Tomohiro Kurosaki,

    1. Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
    2. Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan.
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  • Yuichi Aiba,

    1. Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan.
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  • Kohei Kometani,

    1. Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan.
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  • Saya Moriyama,

    1. Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
    2. Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan.
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  • Yoshimasa Takahashi

    1. Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan.
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Tomohiro Kurosaki
Laboratory of Lymphocyte Differentiation
WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
Tel.: +81 45 503 7019
Fax: +81 45 503 7018
e-mail: kurosaki@rcai.riken.jp

Abstract

Summary:  Memory antibody responses are typically seen to T-cell-dependent antigens and are characterized by the rapid production of high titers of high-affinity antigen-specific antibody. The hallmark of T-cell-dependent memory B cells is their expression of a somatically mutated, isotype-switched B-cell antigen receptor, features that are mainly generated in germinal centers. Classical studies have focused on isotype-switched memory B cells (mainly IgG isotype) and demonstrated their unique intrinsic properties in terms of localization and responsiveness to antigen re-exposure. However, recent advances in monitoring antigen-experienced B cells have revealed the considerable heterogeneity of memory B cells, which include unswitched IgM+ and/or unmutated memory B cells. The IgM and IgG type memory B cells reside in distinct locations and appear to possess distinct origins and effector functions, together orchestrating humoral memory responses.

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