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Regulatory T cells and Foxp3

Authors


Alexander Y. Rudensky
Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center
1275 York Avenue, New York, NY 10065, USA
Tel.: +1 646 888 3109
Fax: +1 646 422 0453
e-mail: rudenska@mskcc.org

Abstract

Summary:  Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune-mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.

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