Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases

  1. Oliver T. Burton,
  2. Hans C. Oettgen

Article first published online: 20 JUN 2011

DOI: 10.1111/j.1600-065X.2011.01024.x

Issue

Immunological Reviews

Immunological Reviews

Special Issue: Allergic Responses

Volume 242, Issue 1, pages 128–143, July 2011

Additional Information

How to Cite

Burton, O. T. and Oettgen, H. C. (2011), Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunological Reviews, 242: 128–143. doi: 10.1111/j.1600-065X.2011.01024.x

Author Information

  1. Division of Immunology, Children’s Hospital, Harvard Medical School, Boston, MA, USA.

*Oliver T. Burton 10005D, Karp-10 1 Blackfan Circle Boston, MA 02115, USA Tel.: +1 617 919 2452 Fax: +1 617 730 0528 e-mail: oliver.burton@childrens.harvard.edu

Publication History

  1. Issue published online: 20 JUN 2011
  2. Article first published online: 20 JUN 2011

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Keywords:

  • IgE;
  • allergy;
  • mast cell

Summary:  Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.

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