Development and evolution of RORγt+ cells in a microbe’s world

  1. Gérard Eberl1,2

Article first published online: 15 DEC 2011

DOI: 10.1111/j.1600-065X.2011.01071.x

Issue

Immunological Reviews

Immunological Reviews

Special Issue: Microbial Influences on Immune Function

Volume 245, Issue 1, pages 177–188, January 2012

Additional Information

How to Cite

Eberl, G. (2012), Development and evolution of RORγt+ cells in a microbe’s world. Immunological Reviews, 245: 177–188. doi: 10.1111/j.1600-065X.2011.01071.x

Author Information

  1. 1

    Lymphoid Tissue Development Unit, Institut Pasteur, Paris, France.

  2. 2

    CNRS, URA1961, Paris, France.

*Gérard Eberl Lymphoid Tissue Development Unit Institut Pasteur 25 rue du Dr Roux 75724 Paris, France Tel.: +33 1 44 38 94 46 Fax: +33 1 40 61 32 04 e-mail: gerard.eberl@pasteur.fr

Publication History

  1. Issue published online: 15 DEC 2011
  2. Article first published online: 15 DEC 2011

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Keywords:

  • RORγt;
  • Th17 cells;
  • innate lymphoid cells;
  • IL-17;
  • IL-22;
  • symbiotic microbiota

Summary:  The nuclear hormone receptor retinoid-related orphan receptor γt (RORγt) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expressing RORγt are lymphoid tissue inducer cells, a type of innate lymphoid cell (ILC) generated in mammalian fetuses to induce the development of lymph nodes and Peyer’s patches. After birth, RORγt+ ILCs and RORγt+ T cells are involved in the defense of epithelial surfaces against extracellular microbes and play an important role in the intestinal homeostasis with symbiotic microbiota. The development and evolution of RORγt+ cells is intimately associated with the construction of a stable host–microbe interface.

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