Immune modulation during latent herpesvirus infection

Authors


Erik S. Barton
Department of Microbiology & Immunology
Wake Forest University School of Medicine
One Medical Center Blvd, 5138A Gray
Winston-Salem, NC 27157, USA
Tel.: +1 336 716 7589
Fax: +1 336 716 9928
e-mail: ebarton@wfubmc.edu

Abstract

Summary:  Nearly all human beings, by the time they reach adolescence, are infected with multiple herpesviruses. At any given time, this family of viruses accounts for 35–40 billion human infections worldwide, making herpesviruses among the most prevalent pathogens known to exist. Compared to most other viruses, herpesviruses are also unique in that infection lasts the life of the host. Remarkably, despite their prevalence and persistence, little is known about how these viruses interact with their hosts, especially during the clinically asymptomatic phase of infection referred to as latency. This review explores data in human and animal systems that reveal the ability of latent herpesviruses to modulate the immune response to self and environmental antigens. From the perspective of the host, there are both potentially detrimental and surprisingly beneficial effects of this lifelong interaction. The realization that latent herpesvirus infection modulates immune responses in asymptomatic hosts forces us to reconsider what constitutes a ‘normal’ immune system in a healthy individual.

Ancillary