Members of the Copenhagen Study Group for Liver Diseases (CSL) are: T J. Balsløv, M. Bjørneboe, P. Christoffersen, K. Eghøje, V. Faber, S. Gjørup, B. Harvald, Kurt Iversen, O. Jessen, E. Juhl, H. E. Jørgensen, A. R. Krogsgård, S. A. Nørregård, T. Steen Olsen, H. Poulsen, F. Quaade, L. Ranek, F. Raaschou, Å. C. Thomsen, N. Tygstrup & P. Winkel.
Prednisone and chronic liver disease. II. Clinical versus morphological criteria for selection of patients for prednisone treatment
Article first published online: 10 DEC 2008
© 1982 Munksgaard, Copenhagen
Volume 2, Issue 2, pages 113–118, June 1982
How to Cite
Schlichting, P., Christensen, E., Fauerholdt, L., Poulsen, H., Juhl, E., Tygstrup, N. and The Copenhagen Study Group For Liver Diseases (1982), Prednisone and chronic liver disease. II. Clinical versus morphological criteria for selection of patients for prednisone treatment. Liver, 2: 113–118. doi: 10.1111/j.1600-0676.1982.tb00186.x
- Issue published online: 10 DEC 2008
- Article first published online: 10 DEC 2008
- Accepted for publication 25 February 1982
- chronic aggressive hepatitis;
ABSTRACT— A prospective, unblinded, randomized trial of treatment of cirrhosis and chronic aggressive hepatitis (CAH) with prednisone included 484 patients who were divided using both the clinical criteria: non-alcoholic females without ascites, and the morphological criterion: presence of a liver biopsy showing CAH. A total of 164 patients (34%) satisfied the three clinical criteria and biopsies from 95 patients (20%) showed CAH. By a cross-tabulation method between the two sets of criteria, four groups were formed. Evaluation of the treatment effect by means of relative death rate showed that the clinical criteria identified both a group of patients with a beneficial effect of prednisone (p<0.05) and a group with a harmful effect of the treatment (p<0.05). Patients with CAH also had a significant beneficial treatment effect, but patients without CAH showed only an insignificantly harmful effect of treatment. Patients fulfilling both sets of criteria had a beneficial effect of prednisone (p<0.05) and patients lacking both sets had a significantly harmful treatment effect. A significantly better survival was found in patients satisfying the clinical criteria without CAH in the biopsy than in patients with CAH and not fulfilling the clinical criteria (p=0.03). In both the groups of patients with disagreement between the two sets of criteria, a trend towards a beneficial effect of prednisone was found. It is concluded that the simple clinical criteria in comparison with the histological criteria identify a larger group of patients with a beneficial effect of treatment.