New England Deaconess Hospital, Boston, Massachusetts, U.S.A.
Immunocytochemical identification of caeruloplasmin in hepatocytes of patients with Wilson's disease
Article first published online: 10 DEC 2008
© 1982 Munksgaard, Copenhagen
Volume 2, Issue 3, pages 207–211, September 1982
How to Cite
Graul, R. S., Epstein, O., Sherlock, S. and Scheuer, P. J. (1982), Immunocytochemical identification of caeruloplasmin in hepatocytes of patients with Wilson's disease. Liver, 2: 207–211. doi: 10.1111/j.1600-0676.1982.tb00198.x
- Issue published online: 10 DEC 2008
- Article first published online: 10 DEC 2008
- Accepted for publication 28 December 1981
- liver cells;
- immunoenzyme technics;
- hepatolenticular degeneration
ABSTRACT— Decreased serum caeruloplasmin levels in patients with Wilson's disease have been attributed to decreased caeruloplasmin synthesis in the hepatocyte. An immunoperoxidase procedure was used to identify caeruloplasmin in liver biopsies. The pattern of staining in biopsies from patients with Wilson's disease did not differ from the pattern seen in normal adult or neonatal liver. This indicates that immunoreactive caeruloplasmin is synthesized by the liver cell in Wilson's disease. Low serum levels of caeruloplasmin may reflect an abnormality of copper incorporation into the apoprotein or an abnormality of holocaeruloplasmin export.