Microtubular aggregates in human chronic non-A, non-B hepatitis with bridging hepatic necrosis and multinucleated hepatocytic giant cells


Department of Pathology University of Basel Schönbeinstr. 40 CH- 4056 Basel Switzerland


ABSTRACT— A case of chronic non-A, non-B (NANB) hepatitis in a 17-year-old male is reported. The special feature was microtubular aggregates described so far only in experimental NANB hepatitis in chimpanzees. Additional characteristics were a severe chronic active hepatitis with confluent necrosis in a late stage, multinucleated hepatocytic giant cells and nuclear aggregates of 20–27 nm viruslike particles.