The plasma membrane origin of liver-specific protein (LSP)

Authors

  • Donald M. Jensen,

    Corresponding author
    1. Liver Research Laboratory, Section of Digestive Diseases, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, U.S.A.
      Liver Research Laboratory Section of Digestive Diseases Department of Medicine Rush-Presbyterian-St Luke's Medical Center 1753 W. Congress Parkway Chicago Illinois 60612 U.S.A.
    Search for more papers by this author
  • Cathie Hall,

    1. Liver Research Laboratory, Section of Digestive Diseases, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, U.S.A.
    Search for more papers by this author
  • Terrance Majewski

    1. Liver Research Laboratory, Section of Digestive Diseases, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, U.S.A.
    Search for more papers by this author

Liver Research Laboratory Section of Digestive Diseases Department of Medicine Rush-Presbyterian-St Luke's Medical Center 1753 W. Congress Parkway Chicago Illinois 60612 U.S.A.

Abstract

ABSTRACT— Liver-specific lipoprotein (LSP) is a potentially important target antigen for autoimmune liver cell injury, but the complexity of LSP “the preparation” has hindered investigation of anti-LSP immune responses. In the present study, rabbit LSP and isolated liver plasma membranes (LPM) were compared using electron microscopy and marker enzyme analysis to determine the subcellular site of origin of LSP. These results suggest that LSP “the preparation” is highly enriched with plasma membrane.

Ancillary