Chronic hepatitis with nonspecific histological changes. Is it a distinct variant of chronic hepatitis?
Article first published online: 10 DEC 2008
© 1984 Blackwell Munksgaard
Volume 4, Issue 1, pages 55–60, February 1984
How to Cite
Liaw, Y.-F., Sheen, I.-S., Chu, C.-M. and Chen, T.-J. (1984), Chronic hepatitis with nonspecific histological changes. Is it a distinct variant of chronic hepatitis?. Liver, 4: 55–60. doi: 10.1111/j.1600-0676.1984.tb00908.x
- Issue published online: 10 DEC 2008
- Article first published online: 10 DEC 2008
- Accepted for publication 19 September 1983
- chronic hepatitis;
- chronic lobular hepatitis;
- chronic persistent hepatitis;
- hepatitis Be antigen;
- nonspecific reactive hepatitis
ABSTRACT— A longitudinal follow-up study has been undertaken in 62 patients with clinicopathologically verified chronic hepatitis with non-specific reactive histological changes (NSRH) in comparison with 28 patients with chronic persistent hepatitis (CPH), the clinical features of which are quite similar to NSRH. In contrast to the stationary and non-progressive course of CPH, 45.2% of patients with NSRH, either HBsAg positive or negative, ran a fluctuating course with moderate to marked elevation of SGPT (>200 IU/l). In HBsAg-positive patients, only those positive for HBeAg and a few negative for both HBeAg and anti-HBe had fluctuating courses. In addition, patients with apparent clinical and biochemical changes could show histological features of chronic lobular hepatitis (CLH). A few developed chronic active hepatitis and/or cirrhosis on follow-up biopsy. It is concluded that NSRH is a form of chronic hepatitis different from CPH, but similar to or representing a phase of CLH. It is suggested that NSRH should be categorized as CLH in the classification of chronic hepatitis.