Small hepatocellular carcinoma containing many Mallory bodies


Second Department of Pathology School of Medicine Kanazawa University Kanazawa 920 Japan


ABSTRACT— Four cases of small hepatocellular carcinoma (HCC), consisting exclusively of Mallory body (MB)-containing cells, were presented. The MB-containing HCC cells seemed actively proliferating and infiltrated into the surrounding non-neoplastic tissue with a concomitant loss of the hepatic parenchyma. α-fetoprotein was immunohisto-chemically demonstrated in these MB-containing HCC cells. Therefore, the possibility arises that the process by which MBs are formed is a fundamental pathway that on some occasions may be linked with neoplastic transformation.