Does a linear pattern of sinusoidal IgA deposition distinguish between alcoholic and diabetic liver disease?

Authors

  • N. Nagore,

    1. Department of Histopathology, Royal Free Hospital and School of Medicine, Hampstead, London, U.K.
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  • P. J. Scheuer

    Corresponding author
    1. Department of Histopathology, Royal Free Hospital and School of Medicine, Hampstead, London, U.K.
      Royal Free Hospital and School of Medicine Pond St, Hampstead London NW3 2QG U.K.
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Royal Free Hospital and School of Medicine Pond St, Hampstead London NW3 2QG U.K.

Abstract

ABSTRACT— IgA deposition in hepatic sinusoids was demonstrated in liver biopsies from 26 patients with alcohol- or diabetes-related fatty liver and fatty liver hepatitis, and from 13 patients with normal liver or chronic active hepatitis. The pattern and extent of IgA deposition were similar in alcoholic and diabetic patients, a linear, continuous pattern being the most common. Staining for IgA cannot therefore be used to evaluate aetiology of fatty liver hepatitis in these two groups of patients.

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