Transient hepatic fibrin-ring granulomas in a patient with acute hepatitis A

  1. Takeshi Yamamoto1,
  2. Motoyasu Ishii1,*,
  3. Hiroshi Nagura2,
  4. Yutaka Miyazaki3,
  5. Masahito Miura1,
  6. Takehiko Igarashi1,
  7. Takayoshi Toyota1

Article first published online: 10 DEC 2008

DOI: 10.1111/j.1600-0676.1995.tb00685.x

Issue

Liver

Liver

Volume 15, Issue 5, pages 276–279, October 1995

Additional Information

How to Cite

Yamamoto, T., Ishii, M., Nagura, H., Miyazaki, Y., Miura, M., Igarashi, T. and Toyota, T. (1995), Transient hepatic fibrin-ring granulomas in a patient with acute hepatitis A. Liver, 15: 276–279. doi: 10.1111/j.1600-0676.1995.tb00685.x

Author Information

  1. 1

    Third Department of Internal Medicine

  2. 2

    Department of Pathology, Tohoku University School of Medicine

  3. 3

    Tohoku Kosai Hospital, Miyagi, Japan

*Third Department of Internal Medicine, Tohoku University School of Medicine, 1–1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980, Japan

Publication History

  1. Issue published online: 10 DEC 2008
  2. Article first published online: 10 DEC 2008
  3. Received 30 August, accepted for publication 23 December 1994

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (995K)

Keywords:

  • acute hepatitis A;
  • fibrin-ring granuloma

Abstract: A case of acute hepatitis A associated with fibrin-ring granulomas in the liver is presented. Because a relationship between acute hepatitis A infection and granuloma formation had not previously been established, liver specimens were examined from both the hepatitic and recovery phases. Numerous fibrin-ring granulomas were observed in the parenchyma during the hepatitic phase. The cellular components of the granulomas were largely macrophages and CD4-positive T-cells. Granulomas had disappeared completely by the recovery phase. These results suggest that fibrin-ring granulomas were caused by hepatitis A virus infection. This virus may activate macrophages and CD4-positive T-cells through an as-yet undetermined mechanism.

Get PDF (995K)