Abstract: The purpose of this study was to compare results of digital subtraction angiography (DSA), computed tomographic arteriography (CTA), and magnetic resonance imaging (MRI) in the assessment of patients with liver metastases subjected to percutaneous transcatheter intra-arterial chemotherapy. Forty-four patients with liver metastases treated by cyclic percutaneous transcatheter intra-arterial chemotherapy were examined before each cycle by an imaging protocol consisting of DSA and CTA. MRI was added to this protocol in 18 patients. DSA and CTA equally detected thrombosis of the catheter or arteries distal to the catheter tip in 16 examinations. DSA detected arterial reflux in 15 examinations, while CTA detected only one case of reflux. CTA was superior to DSA in demonstrating perfusion abnormalities and superior to MRI in detecting metastases. CT was the only method that demonstrated intratu-moral calcification. In conclusion, in patients with liver metastases subjected to percutaneous transcatheter intra-arterial chemotherapy, DSA is the best method for detection of arterial reflux, whereas CTA is the best method for detection of metastases and demonstration of perfusion abnormalities.