Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: a case report
Article first published online: 9 JAN 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Journal of Medical Primatology
Volume 37, Issue 3, pages 162–165, June 2008
How to Cite
Pirarat, N., Kesdangsakolwut, S., Chotiapisitkul, S. and Assarasakorn, S. (2008), Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: a case report. Journal of Medical Primatology, 37: 162–165. doi: 10.1111/j.1600-0684.2007.00274.x
- Issue published online: 9 JAN 2008
- Article first published online: 9 JAN 2008
- Accepted November 07, 2007.
- diabetes mellitus;
- islet amyloidosis;
- Mandrillus sphinx
Case history The two obese mandrills (Mandrillus sphinx) showed clinical signs of depression, anorexia, hyperglycemia, hypertriglyceridemia, glucosuria, proteinuria and ketonuria. Septic bed sore wounds were noted on both fore and hind limbs.
Results Histopathological study revealed severe islet amyloidosis in both mandrills. Immunohistochemical study using polyclonal anti-cat amylin antibody confirmed derivation of the islet amyloid from islet amyloid polypeptide (IAPP). Cardiomyopathy and myocardial fibrosis were also evident.
Conclusions The present study documents diabetes mellitus in two obese mandrills. Diabetes in these animals had features very similar type 2 diabetes mellitus of humans, including the development of severe, IAPP-derived islet amyloidosis. The mandrill may, therefore, serve as an animal model of human type 2 diabetes mellitus.